New research may offer some hope to women whose fertility has been compromised by the side-effects of cancer therapy or by premature menopause.
In a new study, researchers from Monash University and Prince Henry's Institute of Medical Research found that two proteins, PUMA and NOXA, cause the death of egg cells in the ovaries.
Blocking the activity of the proteins may lead to new strategies to protect women's fertility.
They focused their studies on primordial follicle oocytes, egg cells which provide each woman's lifetime supply of eggs. Low numbers of these egg cells can also cause early menopause.
Associate Professor Clare Scott, an oncologist at The Royal Melbourne and Royal Women's hospitals, said their research showed that when the DNA of egg cells is damaged following exposure to radiation or chemotherapy, PUMA and NOXA trigger the death of the damaged eggs, leading to infertility in many female cancer patients. "PUMA and NOXA can trigger cell death, and have been found to be necessary for the death of many different cell types in response to DNA damage. This removal of damaged cells is a natural process that is essential to maintaining health but, for women undergoing cancer treatment, can be devastating when it leads to infertility."
Associate Professor Jeffrey Kerr from Monash said that when these egg-producing cells were missing the PUMA protein they did not die after being exposed to radiation therapy. "This might ordinarily be cause for concern because you want damaged egg cells to die so as not to produce abnormal offspring. To our great surprise we found that not only did the cells survive being irradiated, they were able to repair the DNA damage they had sustained and could be ovulated and fertilised, producing healthy offspring. When the cells were also missing the NOXA protein, there was even better protection against radiation."
Future treatments could block the function of PUMA, preventing egg cell death in patients undergoing chemotherapy or radiation.
Professor Jock Findlay, head of the Female Reproductive Biology Group at Prince Henry's Institute of Medical Research, said the study could also have implications for delaying menopause. "We know that the timing of menopause is influenced by how many egg cells a female has. Interventions that slow the loss of egg cells from the ovaries could delay premature menopause, prolonging female fertility, such a treatment could have the potential to reduce menopause-associated health conditions, such as osteoporosis and heart disease."
Published in Molecular Cell
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- B0 Meson Lifetime Difference Measured By ATLAS
- Case For Moon: Gateway To Open Ended Human Exploration, With Planetary Protection Central - On The SpaceShow
- Can't Resist Temptation? That May Not Be A Bad Thing
- The Real Cost Of Milk
- Italian Food Scientists Are Tired Of Phony Cheese
- After Losing In Government, Environmental Groups Embrace The Free Market
- Sweet Irony: The Environmental Impacts Of GMO Sugar Science Denial
- "Practically everyone in America owns a car now, though 100 years ago that was not the case. Henry..."
- "The GMO salmon is not part of a solution to feed the hungry. It may reduce bad behavior, but mostly..."
- "I agree about WA fish management. I've been writing those fish managers for years about population..."
- "Thank god that Hank Campbell, a member of the press, has written a common sense article on this..."
- "Okay, that may be true, but we never hear from them. Instead we hear from Environmental Working..."
- Times and Bittman on Sugar Tax: Anti-Scientific and Illogical
- A New Danger at the Grill – Just in Time for Memorial Day Weekend
- Ketamine Better than Haloperidol for Sedation Onset But Not Much Else
- TIps & Tricks To Ward Off Ticks
- What is CRISPR-Cas9 and why do we need to know about it?
- Pancreatic Cancer: Surgery Improves Survival in One-third
- Science instruments of NASA's James Webb Space Telescope successfully installed
- Tiny wasp sniffs out, picks up 'good vibrations' to battle ash borer
- Abundance inequality in freshwater communities has an ecological origin
- Family size and education levels: The right support could reverse long-held theory
- New water-quality data on impact of corn, soybeans on nitrate in Iowa streams