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    PiRNAs That Control Where Epigentic Factors Are Placed In Genome Discovered
    By News Staff | February 21st 2013 09:38 PM | 1 comment | Print | E-mail | Track Comments

    If a genome is the blueprint for life, then the chief architects are  the molecular regulators of epigenetics, say Yale School of Medicine researchers.

    In the past 20 years, scientists have discovered that some proteins, epigenetic factors, traverse the static genome and turn the genes on or off. The staggering number of potential combinations of active and inactive genes explains why a relatively small number of genes can carry out such a wide range of functions. But what guides these epigenetic factors to their target? The answer specialized RNAsb - piRNAs.

    In a new paper, researchers discovered that piRNAs guide epigenetic factors to numerous sites throughout the genome of the fruit fly Drosophila, where these switches work to turn genes on or off. The dramatic change in gene expression patterns found illustrated piRNAs key role in coordinating biological activity.

    "Our genome is like a landscape with lakes, mountains, and rivers, but it is not yet a community or a city full of buildings," said Haifan Lin, director of the Yale Stem Cell Center and senior author of the study. "What this system does is decide where and when to send out the masons, carpenters, and electricians to build a city or a community.

    "This is the first major mechanism discovered that controls where epigenetic factors —the gene switches — are to be placed in the genome."

    Several types of cancers appeared to be triggered when the wrong kinds of piRNAs guide epigenetic factors to activate the wrong genes. Blocking the action of these piRNAs should become a new opportunity to treat cancers, Lin said.

    Citation: Xiao A. Huang, Hang Yin, Sarah Sweeney, Debasish Raha, Michael Snyder, and Haifan Lin, 'A Major Epigenetic Programming Mechanism Guided by piRNAs', Developmental Cell DOI:10.1016/j.devcel.2013.01.023


    Comments

    Nutrient-dependent / Pheromone-controlled Adaptive Evolution: http://dx.doi.org/10.6084/m9.figshare.155672

    Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors http://dx.doi.org/10.3402/snp.v2i0.17338

    "The concept that is extended is the epigenetic tweaking of immense gene networks in ‘superorganisms’ (Lockett, Kucharski, & Maleszka, 2012) that ‘solve problems through the exchange and the selective cancellation and modification of signals (Bear, 2004, p. 330)’."

    "Olfaction and odor receptors provide a clear evolutionary trail that can be followed from unicellular organisms to insects to humans."