It has been a mystery why unusually severe epidemics of influenza occur from time to time, such as in 1947 and 1951, when illness and mortality rates exceeded standard epidemic levels.
The standard model of human influenza virus evolution holds that major influenza pandemics, the largest of which occurred in 1918, are caused by reassortment between human and avian influenza viruses. But seasonal influenza epidemics, which occur each winter in the United States, do not involve the reassortment of genetic material.
Researchers at Pennsylvania State University and the National Institute of Health used an evolutionary analysis of influenza viruses sampled from 1918 – 2005 to investigate the influenza viruses that cause seasonal epidemics in humans, particularly those where mortality was unusually high.
Specifically, the researchers found that the severe influenza epidemics of 1947 and 1951 were caused by genetic reassortment events in which two human influenza viruses of the same H1N1 strain exchanged genetic material, producing a new hybrid virus in both cases.
These new findings suggest that the evolution of seasonal influenza is more complex than previously thought, and that multiple forms of the same strain co-circulate and re-assort within a single population, rapidly generating genetically novel viruses with the potential to ignite major epidemics.
It is therefore critical that intensive surveillance is undertaken to capture the full extent of influenza genetic diversity that co-circulates at a given time, particularly as an aid to vaccine design.
- Amitabh Avasthi
Nelson MI, Viboud C, Simonsen L, Bennett RT, Griesemer SB, et al. (2008) Multiple Reassortment Events in the Evolutionary History of H1N1 Influenza A Virus Since 1918. PLoS Pathog 4(2): e1000012. doi:10.1371/journal.ppat.1000012
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- What May Be Missing From Quantum Computing - A Quantum Middle Man
- Math, Time and Obesity
- Almost One In Three US Adults Owns A Gun But Murder Rates Have Plummeted
- Patients With Recurrent Depression Have Smaller Hippocampi
- Radiation Detectors Click By Design
- Obese Teens Are Less Likely To Use Contraception
- Lexus Hoverboard Gets Off The Ground
- "The chart (and the framing by the underlying statstics) is making more of an evangelical case than..."
- "For the data, see Richardson EG1, Hemenway D. 2011: Homicide, suicide, and unintentional firearm..."
- "Hello IR,if you apply to one of the positions we'll open next month (5 or 6 if I'm not mistaken)..."
- "Nice and pedagogic explanation. But check that in the last paragraph, it should be 100 times less..."
- "Why does special relativity work? Does it? Take a look: DOI: 10.13140/RG.2.1.3461.7763/1 ..."