Cells obtained from menstrual blood, termed 'endometrial regenerative cells' (ERCs), are capable of restoring blood flow in an animal model of advanced peripheral artery disease, according to a study published today in Journal of Translational Medicine. When circulation-blocked mice were treated with ERC injections, circulation and functionality were restored.
Critical limb ischemia, an advanced form of peripheral artery disease, causes approximately 150,000 amputations per year in the US. Currently there are no medical or surgical interventions that are effective in the advanced stages of the disease. ERCs are cells taken from menstrual blood that are capable of forming into at least 9 different tissue types, including heart, liver and lung. Their discovery won the 'Medicine Research Award of the Year' award for BioMed Central's Research Awards in 2007.
Dr. Michael Murphy, a vascular surgeon from Indiana University and lead author of this study has already performed clinical trials with adult stem cells for patients with peripheral artery disease. He stated, "The advantage of ERCs is that they can be used in an 'off the shelf' manner, meaning they can be delivered to the point of care, do not require matching, and are easily injectable without the need for complex equipment."
The experiments were performed as a collaboration between University of Western Ontario, Scripps Research Institute, Indiana University, and several other academic centers. The ERC cell population is currently being developed by the US publicly traded company Medistem Inc, who supported these studies.
"We are proud of assembling such a strong, clinically experienced team to contribute to these studies" said Dr. Thomas Ichim, CEO of Medistem. "Dr. Ewa Carrier and Suman Kambhampati are hematologists who use stem cells on a regular basis, Dr. Angle is a vascular surgeon, who like Dr. Murphy sees CLI on a daily basis, and Dr. Amit Patel has performed numerous cardiac stem cell clinical trials. With such a team that understands not only the science, but also the practical implementation, we feel we are well positioned to translate this discovery into a practical therapy in the near future".
Article: Michael P Murphy, Hao Wang, Amit N Patel, Suman Kambhampati, Niren Angle, Kyle W Chan, Annette M Marleau, Andrew Pyszniak, Ewa Carrier, Thomas E Ichim and Neil H Riordan, 'Allogenic Endometrial Regenerative Cells: An "Off the Shelf Solution" For Critical Limb Ischemia?', Journal of Translational Medicine
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Could You See Moon City Lights Or A Greenhouse From Earth? Just For Fun
- The Alleged Perversion of Geoff Marcy and Sexual Harassment.
- Mother Jones Hates Scientists - And Their Bias Shows
- The Plot Of The Week: Light New Bosons Below The J/Psi
- Hand And Arm Movement To Quadriplegic Patients Restored
- To Make EU Food Sector Renewable Energy Viable, Less Meat And More...Organic Veggies?
- 'Blind Analysis' Used In Physics Could Reduce Bias In Social And Life Sciences Papers
- "One of their media enablers - Lisa Graves, who runs the partisan organization behind SourceWatch..."
- "It’s interesting (and telling) that MJ is saying they “won” the case and that this is a case..."
- "Thanks! I've rewritten it to: The other bit of information we need is that with each increase..."
- "You don't know me, you don't know anything about me - but if you were not reflexively defending..."
- "Yes, it's a unfortunate place for that event. The problem is that the dimuon mass cannot be smaller..."
- ACSH Talks Science Outreach At The Western Plant Health Association Meeting
- OxyContin-for-Kids Debate, Now National, Intensifies
- Golden Rice Moves Closer to Reality in Asia
- C. Diff. Can Be Controlled, With Relative Ease
- FDA-Approved Test for Meningitis is a Home Run
- Trends In Smoking – Chinese Men In Peril, American Women Get Better Cessation
- Ceritinib in advanced lung cancer: No hint of added benefit
- Public agencies less likely than private firms to comply with environmental regulations
- Spring to come 3 weeks earlier to the United States
- What does it take to escape the water? Plankton have clues
- Poor children will be hit hardest by government welfare cuts, warn experts