Cells obtained from menstrual blood, termed 'endometrial regenerative cells' (ERCs), are capable of restoring blood flow in an animal model of advanced peripheral artery disease, according to a study published today in Journal of Translational Medicine. When circulation-blocked mice were treated with ERC injections, circulation and functionality were restored.
Critical limb ischemia, an advanced form of peripheral artery disease, causes approximately 150,000 amputations per year in the US. Currently there are no medical or surgical interventions that are effective in the advanced stages of the disease. ERCs are cells taken from menstrual blood that are capable of forming into at least 9 different tissue types, including heart, liver and lung. Their discovery won the 'Medicine Research Award of the Year' award for BioMed Central's Research Awards in 2007.
Dr. Michael Murphy, a vascular surgeon from Indiana University and lead author of this study has already performed clinical trials with adult stem cells for patients with peripheral artery disease. He stated, "The advantage of ERCs is that they can be used in an 'off the shelf' manner, meaning they can be delivered to the point of care, do not require matching, and are easily injectable without the need for complex equipment."
The experiments were performed as a collaboration between University of Western Ontario, Scripps Research Institute, Indiana University, and several other academic centers. The ERC cell population is currently being developed by the US publicly traded company Medistem Inc, who supported these studies.
"We are proud of assembling such a strong, clinically experienced team to contribute to these studies" said Dr. Thomas Ichim, CEO of Medistem. "Dr. Ewa Carrier and Suman Kambhampati are hematologists who use stem cells on a regular basis, Dr. Angle is a vascular surgeon, who like Dr. Murphy sees CLI on a daily basis, and Dr. Amit Patel has performed numerous cardiac stem cell clinical trials. With such a team that understands not only the science, but also the practical implementation, we feel we are well positioned to translate this discovery into a practical therapy in the near future".
Article: Michael P Murphy, Hao Wang, Amit N Patel, Suman Kambhampati, Niren Angle, Kyle W Chan, Annette M Marleau, Andrew Pyszniak, Ewa Carrier, Thomas E Ichim and Neil H Riordan, 'Allogenic Endometrial Regenerative Cells: An "Off the Shelf Solution" For Critical Limb Ischemia?', Journal of Translational Medicine
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Part I: Bee Deaths Mystery Solved? Neonicotinoids (Neonics) May Actually Help Bee Health
- Part II: Bee Deaths And CCD - Flawed Chensheng Lu Harvard Studies Endanger Bees
- Bitcoin And Anonymity: User's Identity Can Be Revealed Much Easier Than Thought
- Not Neonics: Parasites Are Bad For Honey Bees
- Violence, Sex And Taboo: The Original Brothers Grimm Fairy Tales Back In Print
- Volunteer-Based Peer Review: A Success
- Diversity Fatigue: Why Businesses Struggle To Close The Gender Gap
- "Which papers? Did I miss something? It seemed like your claim was based on those two papers (Lu..."
- "Pike squares, infantry squares, and other tactical formations are obsolete, but phalanxes and testudo..."
- "Revolutions are not funded by their own government. If it were a revolution, investment in the..."
- "Artificial gravity by radial acceleration doesn't need any testing. Every child has tested hurling..."
- "The control hives didn't have nicotine. I wonder if bees in North Carolina have higher susceptibility..."
- Shaping the future of energy storage with conductive clay
- Star Trek-like invisible shield found thousands of miles above Earth
- Vaccines may make war on cancer personal
- SU2C-supported research discovers why patients respond to a life-saving melanoma drug
- Researchers identify a natural shield against harmful radiation belt