Pharmacology

If you were pregnant, did you ever take a Tylenol?

If not, you have unreal levels of tolerance for discomfort but if you did, and you think your child is hyperactive, a new study may have some answers. Not 'why' answers, just a 'perhaps' answer. But look for mainstream media to declare that Tylenol causes attention-deficit/hyperactivity disorder (ADHD) in kids.

Ecstasy, marijuana (including synthetic cannabinoids sold as ‘Spice’ and ‘Incense’) and various psychoactive ‘legal highs’ have surged in popularity and Canada has become a major criminal hub for ecstasy. 

Recent deaths have been linked to paramethoxymethamphetamine (PMMA) in ecstasy pills and with Canadian producing most of the ecstasy in the North American market, a timely paper in Drug Science Policy and Law looks at trends in ecstasy adulteration and the facts around PMA/PMMA-linked deaths. 

In America, social authoritarians are ban-happy but the Canadian authors also argue for an alternative to a new ban.

The review finds: 

Last week, an article appeared in The Lancet Neurology (doi:10.1016/S1474-4422(13)70278-3) which reviewed studies and asserted that there is a "pandemic" of developmental toxicity. This led to a press release and a variety of stories in the media linking things like pesticides to brain disorders in children.

It would be almost impossible to find a better example of the difficulties that face the pharmaceutical industry than the campaign against hepatitis C.

Unfortunately, this example is now at the expense of Vertex Pharmaceuticals, a small, but top-notch drug discovery organization that began as a biotech startup in 1989.

The world's oceans contain algae that produce certain chemicals
that can accumulate in seafood and are known to cause brain damage.

This natural neurotoxin, domoic acid, is a very stable and heat resistant and is also toxic to the kidneys, but at much lower concentrations than guidance has suggested, according to an upcoming study in the Journal of the American Society of Nephrology (JASN).

Most medications prescribed in primary care contain animal derived products.

Are they suitable for vegetarians?

Dietary preferences are common in the general population. Influences such as religion, culture, economic status, environmental concern and personal preferences all play a part in the foods that people choose to consume. Most doctors are unaware that commonly prescribed drugs contain animal products and would be surprised that it matters. But most patients are not aware either and if they have a dietary preference it might impact the medicines they are willing to take also. 

Survey results analyzed by psychologists at The Fenway Institute, an advocacy group for the lesbian, gay, bisexual, and transgender (LGBT) community, found that gay and bisexual boys use anabolic-androgenic steroids (AAS) at rates much higher than their straight counterparts - almost 6X higher.
Middle-aged women the world over are now...chuckling.

At least I imagine they are, given the news this week that testosterone supplementation may increase the risk of heart disease.

If you already have heart disease.

Or if you’re over 65.

An analysis of routine insurance data from the Barmer GEK statutory health insurance company shows that during the years 2005 to 2012, antipsychotic prescriptions for kids in Germany increased a lot. 

Marijuana use has been involved in a sharp increase in fatal motor vehicle crashes, with rates nearly tripling since 1999. 

The prevalence of non-alcohol drugs detected in fatally injured drivers in the U.S. has been steadily rising and tripled from 1999 to 2010. Marijuana is the most commonly detected non-alcohol drug involved.