Pharmacology

University of Cincinnati researchers say they have discovered a new therapy for transplant patients; targeting the antibody-producing plasma cells that can cause organ rejection.  Steve Woodle, MD, and colleagues found that a cancer drug. bortezomib, that is used to treat multiple myeloma, or cancer of the plasma cells, is also effective in treating rejection episodes caused by antibodies that target transplanted kidneys and reversing rejection episodes that did not respond to standard therapies.

B-lymphocytes, or B cells, play a large role in the humoral immune response by making immune proteins that attack transplanted organs.
People can make their own salicylic acid (SA), the principal metabolite of aspirin. SA that gives aspirin its famous action on pain, fever, and inflammation is now looking like a star in its own "class" of bioregulators.
Fish oil protects against deaths from heart problems, but doesn't provide a clear benefit in heart rhythm problems (arrhythmias), according a study published on bmj.com today.

Consuming oily fish at least two to four times a week is recommended for patients after a heart attack. But the evidence for the protective effect of fish oil supplements is based on one large trial from over 10 years ago. More recent trials have showed no beneficial effect of fish oil on patient outcomes.

Since its discovery in the 18th century, cocaine has been a scourge of western society. Strongly stimulating human reward centers in low doses, cocaine is extremely addictive and can be fatal in high doses.

But this potent compound did not evolve to ensnare humans in addiction, it is a powerful insect neurotoxin, protecting coca bushes from munching insects - without rewarding them.

A study headed by researchers from the University of Barcelona (UB) shows that caffeine has a greater effect on men than women, and that these effects start just 10 minutes after it is drunk. In addition, contrary to what was previously thought, it has also been shown that decaffeinated coffee also produces an increased state of alertness. 

“Numerous studies have demonstrated the stimulant effects of caffeine, but none of these have looked at their effects in terms of the consumer’s gender,” Ana Adan, lead author of the study and a researcher in the Psychiatry and Clinical Psychobiology Department of the UB, tells SINC. 
Good quality extra-virgin olive oil contains health-relevant chemicals, 'phytochemicals', that can trigger cancer cell death. New research published in the open access journal BMC Cancer sheds more light on the suspected association between olive oil-rich Mediterranean diets and reductions in breast cancer risk.


As a result of Sir Tom Jones citing his use of Vocalzone on Top Gear (14/12/2008) Kestrel, the (Poole based) makers of the Throat Pastille which is also known to be used Snoop Dogg, Madonna, Joss Stone and Robbie Williams, has been inundated with enquiries from literally thousands of aspiring singers that watch the program.


Sir Tom Jones was asked by Jeremy Clarkson on Top Gear if he took anything to maintain his voice.


A dose of the hormone Oxytocin reduces the stress hormone Cortisol in arguing couples. In addition, Oxytocin strengthens positive behaviour, as researchers at the University of Zurich have discovered.

Various studies in recent years have shown that the hormone Oxytocin in the brain of mammals can help in regulating social behavior. Beate Ditzen from the Psychological Institute of the UZH has now, together with colleagues from the University of Zurich, examined the hormone particularly in terms of the behavior in partnerships. 
Insufficient vitamin D can stunt growth and foster weight gain during puberty, according to a new study published in the Journal of Clinical Endocrinology&Metabolism. Even in sun-drenched California, where scientists from the McGill University Health Centre (MUHC) and the University of Southern California conducted their study, vitamin D deficiency was found to cause higher body mass and shorter stature in girls at the peak of their growing spurt.
Two common diabetes drugs — rosiglitazone and pioglitazone — are linked to higher fracture rates in women, according to a meta-analysis in CMAJ by a team of researchers from the University of East Anglia in the United Kingdom and Wake Forest University in the United States.

The drugs, called thiazolidinediones, help improve glycemic control and decrease insulin resistance in patients with diabetes.