Induced pluripotent stem cell (iPSC) research in the last 2 years has faced many twists and turns. With scientists uncovering a number of disturbing genomic abnormalities in these cells, the future of iPSC technology looked like a sea of despair.
But lucky for those who persisted in this field of research, recent findings based on deep genome sequencing data revealed that these so-called "genomic abnormalities" simply reflect the normal genomic quirks of the original somatic cells from which iPSCs were derived.
Cheng et al, 2012 (Cell Stem Cell 10, 337–344)Young et al 2012 (Cell Stem Cell 10, 1-13)
Induced pluripotent stem cell research faces many challenges- but persistence pays off
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