Scientists have discovered a mutation responsible for cancer progression, a finding with potential implications for the development of treatment against not one, but a series of cancer types, since this mutation can be linked to an abnormality recently discovered to exist in all malignancies. The discovery has just been published in Nature Genetics.(1)
Cooperation, despite being now considered the third force of evolution, just behind mutation and natural selection, is difficult to explain in the context of an evolutionary process based on competition between individuals and selfish behaviour. But this puzzle, that has haunted scientists for decades, is now a little closer to be solved by research about to be published on the journal Physical Review Letters.
A research team in Portugal and the US has found for the first time nicotine receptors in the taste buds. In fact, although most of the toxicity of smoking is linked to other components, it is nicotine that leads to smoking addiction and until now it was believed that this substance had to migrate into the brain to bind its specific receptors and provoke its effects.
Asymmetry is crucial for the heart proper functioning, and now, scientists from the Institute Gulbenkian of Science in Portugal and Harvard University, have discovered that a family of genes, called Nodal, is crucial determining this asymmetry by controlling the speed and direction of the heart muscle cells during embryonic development.
The finding, by helping to understand how the heart develops, is a step closer to intervention and is of particular importance if we consider that problems in heart asymmetry are the main cause of heart congenital diseases that can affect as much as 8 out of 1000 newborns. The research appears in a special December issue of the journal Development Dynamics 1 dedicated to left-right asymmetry development.
The Iberian Lynx is now the most endangered cat in the world with only about 160 animals remaining in the wild and, despite extensive research and millions of Euros spent in decades of protection, nothing seems capable to stop this decline.
Scientists in Cambridge, UK, using a mouse with a human chromosome in its cells, discovered that gene expression, contrary to what was previously thought, is mostly controlled by regulatory DNA sequences.
Mice and humans (and most vertebrates) share the majority of their genes but a distinct gene regulation – so, when and where these shared genes become activated – assures their many individual characteristics, and knowledge of this regulation is crucial if we want one day to be able to control gene expression.