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    Better Statistics Insight Could Solve Missing Heritability Problem In Genome-Wide Association Studies
    By News Staff | May 7th 2014 09:19 AM | Print | E-mail | Track Comments

    The modern world of Big Data increasingly requires knowledge of statistics and biologists are scrambling to master that along with all of the expertise needed to solve mysteries of nature.

    A new statistical framework could help, according to a new paper, because it can substantially increase the power of genome-wide association studies (GWAS) to detect genetic influences on human disease.

    Despite the proliferation of
    genome-wide association studies
    , the associations found so far have largely failed to account for the known effects of genes on complex disease — the problem of "missing heritability." Standard approaches also struggle to find combinations of multiple genes that affect disease risk in complex ways, known as genetic interactions.

    The new framework enhances the ability to detect genetic associations and interactions by taking advantage of data from other genomic studies of the same population. Such information is increasingly abundant for many human populations.

    The authors demonstrated that their method improves performance over standard approaches. They also re-examined real
    genome-wide association studies
    data to find promising new candidates for genetic interactions that affect bipolar disorder, coronary artery disease, Crohn's disease, and rheumatoid arthritis.

    "We think practically everyone who's ever done a case-control
    genome-wide association studies
    could benefit from reanalyzing their data in this way," said author Saharon Rosset, associate professor of statistics at Tel Aviv University.

    "This paper offers a significant advance in mapping genes involved in disease. The approach makes use of available data to substantially improve the ability to identify genetic components of disease," said Mark Johnston, Editor-in-Chief of the journal GENETICS, which published the paper.