Endocarditis is a dangerous and sometimes lethal infection of the heart sometimes caused after a dental procedure.
is a bacterium best known for causing cavities. The bacteria reside in dental plaque, an architecturally sophisticated goo composed of an elaborate molecular matrix created by S. mutans that allows the bacteria to inhabit and thrive in our oral cavity. There, they churn out acid that erodes our teeth. Ordinarily, that is the end of it, but sometimes after a dental procedure or even vigorous flossing, the bacteria enter the bloodstream. There, the immune system usually destroys them but occasionally sometimes they travel to the heart and colonize its tissue, especially heart valves. The bacteria can cause endocarditis – inflammation of heart valves – which can be deadly. Infection by S. mutans is a leading cause of the condition.
"When I first learned that S. mutans sometimes can live in the heart, I asked myself: Why in the world are these bacteria, which normally live in the mouth, in the heart? I was intrigued. And I began investigating how they get there and survive there," said Jacqueline Abranches, Ph.D., a microbiologist and the corresponding author of the study.
Abranches and her team at the University's Center for Oral Biology discovered that a collagen-binding protein known as CNM gives S. mutans its ability to invade heart tissue. In laboratory experiments, scientists found that strains with CNM are able to invade heart cells, and strains without CNM are not.
When the team knocked out the gene for CNM in strains where it's normally present, the bacteria were unable to invade heart tissue. Without CNM, the bacteria simply couldn't gain a foothold; their ability to adhere was about one-tenth of what it was with CNM.
The team also studied the response of wax worms to the various strains of S. mutans. They found that strains without CNM were rarely lethal to the worms, while strains with the protein were lethal 90 percent of the time. Then, when Abranches' team knocked out CNM in those strains, they were no longer lethal – those worms thrived.
The work may someday enable doctors to prevent S. mutans from invading heart tissue. Even sooner, though, since some strains of S. mutans have CNM and others do not, the research may enable doctors to gauge a patient's vulnerability to a heart infection caused by the bacteria.
Abranches has identified five specific strains of S. mutans that carry the CNM protein, out of more than three dozen strains examined. CNM is not found in the most common type of S. mutans found in people, type C, but is present in rarer types of S. mutans, including types E and F.
"It may be that CNM can serve as a biomarker of the most virulent strains of S. mutans," said Abranches, a research assistant professor in the Department of Microbiology and Immunology. "When patients with cardiac problems go to the dentist, perhaps those patients will be screened to see if they carry the protein. If they do, the dentist might treat them more aggressively with preventive antibiotics, for example."
Until more research is done and a screening or preventive tool is in place, Abranches says the usual advice for good oral health still stands for everyone.
"No matter what types of bacteria a person has in his or her mouth, they should do the same things to maintain good oral health. They should brush and floss their teeth regularly – the smaller the number of S. mutans in your mouth, the healthier you'll be. Use a fluoride rinse before you go to bed at night. And eat a healthy diet, keeping sugar to a minimum," added Abranches.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Giddings: The 750 GeV Diphoton Resonance Is A Graviton
- Why Your Muscles Get Less Sore As You Stick With Your Gym Routine
- Inconvenient Truth: There Are Synthetic Pesticide Residues On Organic
- No Higgs Needed: 5 Ways Particle Accelerators Have Changed The World
- Future Transatlantic Flight Delays Blamed On Global Warming
- Native Grass Make Super-Thin Condoms
- A.I. May Tell Us What's Going To Be Big In Science This Year
- "Does the emitted photon from carbon dioxide have EXACTLY the same wavelength as the absorbed photon..."
- " from: http://wattsupwiththat.com/2013/12/02/history-falsifies-climate-alarmist-sea-level-claims/..."
- "Thanks, didn't know about those. But it could also be a shower of hail stones, using the wikipedia..."
- "Are you saying that the sea level data are wrong? I'm just quoting it. If so, please note your data...."
- "For a good place to start, concerning causality as it relates to physics and the mathematics of..."
- Benefits of re-growing secondary forests explored through international collaboration
- Terahertz wireless technology could bring fiber-optic speeds out of a fiber
- Researchers discover a genetic mutation that prevents diabetes complications
- Light and manganese to discover the source of submerged Roman marble
- 'Electronic nose' from a Russian scientist will help to diagnose diseases