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    What Caused Sweden's Celiac 'Epidemic'?
    By News Staff | December 19th 2012 02:21 AM | 12 comments | Print | E-mail | Track Comments

    Celiac disease, defined as a 'chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals', affects about one percent of the population but occasional 'epidemics' have been noticed along with a seasonal variation in number of cases diagnosed. 

    Sweden has noticed an "epidemic" of celiac disease in children below two years of age but since celiac disease is considered multifactorial not much is known about potential risk- or protecting factors. But Swedish researchers now say repeated infections early in life increase the risk for getting it.

    The Sweden-based, case controlled, study compared the health history of children diagnosed with celiac disease (475 cases, 950 referents) to similar children without celiac disease. The average age of development of celiac was at 11 months old, with diagnosis four months later. The team from Umeå University and Uppsala University found that having three or more infections (reported by parents) increased risk of celiac disease by 50%. Gastroenteritis on its own increased the risk by almost 80%.  The final analyses included 954 children, 373 cases and 581 referents. Exposure information was obtained by questionnaires which included family characteristics, infant feeding, and the child's general health.

    The highest risk was seen for children who had several infections before they were six months old and who also ate large amounts (compared to small/medium amounts) of gluten, soon after gluten was introduced, and if breastfeeding had stopped before the introduction of gluten to the diet.

    Dr Anna Myléus, who led this study, explained, "While we do not know if the increased risk is due to a genetic predisposition to both infection and celiac disease, our results highlight the importance of breast feeding in reducing risk of celiac disease, especially for an infant who has frequent infections."

    Citation: Anna Myléus, Olle Hernell, Leif Gothefors, Marie-Louise Hammarström, Lars-Åke Persson, Hans Stenlund and Anneli Ivarsson, 'Early infections are associated with increased risk for celiac disease: an incident case-referent study', BMC Pediatrics 2012, 12:194 doi:10.1186/1471-2431-12-194


    Comments

    MikeCrow
    And what's given to people with infections?

    Antibiotics.
    Never is a long time.
    Gerhard Adam
    ???

    Mundus vult decipi
    MikeCrow
    I wrote a reply yesterday, I guess I didn't hit submit.

    I said something like, "I though of all the people who read it, you'd be the one to get my comment.
    Antibiotics kills gut microbes"
    Never is a long time.
    Gerhard Adam
    That's what I get for only half paying attention.
    Mundus vult decipi
    Are you sure that those Swedish babies aren't pretending to be celiac, just to be fashionable and keep up with the Gagas?

    Hank
    There's no evidence that babies in Sweden watch Dr. Oz.  They looked at actual cases of celiac, these babies did not self-diagnose as part of a diet fad.

    Did Lady Gaga lose any weight?  Shocks to the body are good for metabolism, she could have lost weight giving up carbs too, but is she still doing that or has she moved onto something else?
    Infection --> Antibiotics --> less 'good' bacteria in the gut --> problems.

    jeffrey dach md
    Modern wheat was genetically modified in the 1970's  by Norman Borlaug, a plant geneticist who won the Nobel Prize and Congressional Gold Medal for developing a high yield dwarf wheat which was a blessing because it saved two or three billion people from dying of starvation.  The "curse" is the magnified adverse health effects.  Changes to the gliadin protein in the new wheat have quadrupled the incidence of celiac disease and auto-immune disease.  Opiate activity of semi-digested peptide fragments from the gliadin protein stimulate the appetite causing increased caloric intake and obesity.  Amylopectin component causes hyperglycemia and insulin resistance diabetes, now reaching epidemic proportions in our population.  For genetically susceptible people with celiac or autoimmune disease, eliminating wheat from the diet is curative.  Your mainstream rheumatologist, gasteroenterologist or endocrinologist will deny or reject this connection, even though it is now published in mainstream medical journals.
    Jeffrey Dach MD 7450 Griffin Road Suite 190 Davie, Fl 33314 telephone 954-983-1443
    Hank
    Your mainstream rheumatologist, gasteroenterologist or endocrinologist will deny or reject this connection
    Not sure why. We all know what alternative medicine is called when it actually survives the scientific method and is not made up conjecture and a conspiratorial correlation - regular medicine.

    That is not to say your claims hold up - you seem to have chosen an explanation you like.  Since all that requires is two curves in the same direction I could easily claim the price of steel has resulted in more of these cases occurring.
    jeffrey dach md
    "Not sure why"
    Same reason why Warren and Marshall were ridiculed for 20 years for suggesting that gastric ulcers were caused by a bacterial infection.   Paradigm shifts in medicine are ignored or denied for many years until  finally they are accepted and given a Nobel Prize.  Warren and Marshall got theirs in 2005.

    Allessio Fasano's group  from the University of Maryland have been making most of the progeress in this area  over the past 10 years, and much of it is now published in the mainstream medical literature.

    regards

    Jeffrey Dach MD
    Jeffrey Dach MD 7450 Griffin Road Suite 190 Davie, Fl 33314 telephone 954-983-1443
    Hank
    Paradigm shifts in medicine are ignored or denied for many years until finally they are accepted and given a Nobel Prize.
    After this gets a Nobel Prize....
    Opiate activity of semi-digested peptide fragments from the gliadin protein stimulate the appetite causing increased caloric intake and obesity
    ...I will be sure to withdraw my skepticism.

    I don't care if you tell people to go on a gluten-free diet, even if they don't have celiac. Just like I don't care if someone's religion tells them not to eat pork.  But it isn't science. Invoking Galileo or ulcers is done by literally everyone engaged in homeopathy and alternative medicine, so you shouldn't do it if you want to be taken seriously.

    jeffrey dach md
    Opioid activity of peptide fragments in wheat as well as other plants has been known for over 30 years.  I doubt you will ever see a Nobel Prize for it though.

    Opioid agonists have many psychoactive properties, one of which is stimulation of the appetite center  in both animal and human experiments.  Block opioid receptors with an opioid receptor antagonist drug such as naltrexone, or eliminate the wheat consumption in both animal and human experiments, and caloric intake decreases with associated weight loss.   A few references on opiod activity of wheat peptides for you:

    J Biol Chem. 1979 Apr 10;254(7):2446-9.
    Opioid peptides derived from food proteins. The exorphins.
    Zioudrou C, Streaty RA, Klee WA.

    Peptides. 1984 Nov-Dec;5(6):1139-47.
    Demonstration of high opioid-like activity in isolated peptides from wheat gluten hydrolysates.
    Huebner FR, Lieberman KW, Rubino RP, Wall JS.

    FEBS Lett. 1992 Jan 13;296(1):107-11.
    Opioid peptides derived from wheat gluten: their isolation and characterization.
    Fukudome S, Yoshikawa M. Source Research Control Department, Nisshin Flour Milling Co., Ltd., Tokyo, Japan.

    Curr Pharm Des. 2003;9(16):1325-30.
    Delta opioid peptides derived from plant proteins.
    Yoshikawa M, Takahashi M, Yang S. Source Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan.

    regards from

    Jeffrey Dach MD 7450 Griffin Road Suite 190 Davie, Fl 33314 telephone 954-983-1443