Dr. Peter K. Gregersen says he has finally closed the circle between key genes and more than a 1,000 patients with rheumatoid arthritis. The genes will help tell the story of how the immune system works to create specific antibodies that in turn increase a person’s risk for this crippling disease.
Gregersen's group conducted genome-wide scans to identify polymorphisms, or genetic variants, that are associated with the inflammatory condition and can be used to understand the triggers of the disease. This will provide key insights into the pathways underlying rheumatoid arthritis and other autoimmune diseases. It may ultimately provide tests to predict who will respond to the available new treatments.
Logic or feeling. Left-brained or right-brained. The terms have become part of the lexicon for categorizing intellectual and artistic people. It turns out there may be more than just wishful thinking in labelling people. New research has furthered our understanding of the different roles of the left and right sides of our brains.
A study led by the University of Exeter has highlighted differences in the ability of people to perform basic tasks, depending on whether the left or right sides of their brains have been damaged by a stroke. The research identified the role of the right side of the brain in noticing and correcting errors.
A simple, cheap treatment using just oxygen could allow growers to store organic produce for longer and go a long way towards reducing the price of organic fruit and vegetables.
Currently UK shoppers have to pay twice as much for some organic products. Organic apples, for example, are around double the price of conventionally grown apples in Sainbury’s, Waitrose and Tesco.
Northwestern University researchers have discovered a drug that slows – and may even halt – the progression of Parkinson’s disease. The drug rejuvenates aging dopamine cells, whose death in the brain causes the symptoms of this devastating and widespread disease.
D. James Surmeier and his team of researchers have found that isradipine, a drug widely used for hypertension and stroke, restores stressed-out dopamine neurons to their vigorous younger selves.
An international study by researchers at Seattle Children’s Hospital Research Institute, the University of Washington School of Medicine, and Radboud University in Nijmegen, Netherlands has identified a new genetic cause for Joubert syndrome (JS).
Joubert syndrome is an inherited condition that affects development of the cerebellum and brainstem, the structures in the brain that coordinate movements and regulate basic functions such as breathing, swallowing, heart rate and consciousness. The study confirms key information about the genetic changes that cause JS and cellular structures called cilia, conclusively placing JS in a class of recently identified ciliopathic conditions.
More than 26 million people worldwide were estimated to be living with Alzheimer’s disease in 2006, according to a study led by researchers at the Johns Hopkins Bloomberg School of Public Health.
The researchers also concluded the global prevalence of Alzheimer’s disease will grow to more than 106 million by 2050. By that time, 43 percent of those with Alzheimer’s disease will need high-level care, equivalent to that of a nursing home.