A study out tomorrow in Nature by researchers from the Institute of Healthy Ageing at the University College of London and colleagues is questioning the anti-aging effects of sirtuin – which is “just”the most important anti-aging gene of the decade - claiming that its capacity to increase longevity was nothing more than an experimental error, and showing that,once the flaws are corrected, sirtuin has no effect on lifespan.
Cardiovascular diseases (CVD) already account for one third of all global deaths and raising, with effective heart regeneration therapies yet to be developed despite worldwide research efforts. But a new study by scientists from Oxford University and the University of Coimbra in Portugal might have put us a step closer with the discovery of the key molecule regulating the development of several heart and blood vessels’ tissues in the zebrafish embryo.
Scientists have identified a biochemical abnormality behind the potentially fatal neurodegenerative Machado-Joseph disease (MJD) and, using several models of the disease, were able to reverse the problem in what may be a crucial step towards a cure for humans. Currently, the disease is incurable and the patients’ increasing neurodegeneration cannot be stopped.
Mitochondria are better known as the power factories of the cell but in fact they are much more interesting than that. Contrary to the old image in textbooks of round static structures, mitochondria are now known to be incredibly dynamic, shape changing, fusing and dividing according to the multitude of functions they perform in the cell. And now, in a study to be published in the journal Nature Cell Biology, scientists in Italy and Portugal show that mitochondria can also be crucial for the survival of cells during stress.